Guthrie scored the only goal of the game in the first half in Northampton’s victory in the England League Two, as they beat Colchester 1-0 (1-0) away.
Northampton took an early lead when Jon Guthrie scored after 22 minutes, making it 1-0.
In the next round, Colchester take on Mansfield at home at Colchester Community Stadium on Tuesday. Northampton play at home to Rochdale on Saturday.